Associative overdominance, heterozygosity and fitness
نویسندگان
چکیده
منابع مشابه
Hitchhiking and associative overdominance at a microsatellite locus.
The possible effects of a selected locus on a closely linked microsatellite locus are discussed and analyzed in terms of coalescent theory and models of the mutation process. Background selection caused by recurrent deleterious mutations will reduce the variance of allele size at a microsatellite locus. The occasional substitution of advantageous alleles (genetic hitchhiking) will also reduce t...
متن کاملResolving the Conflict Between Associative Overdominance and Background Selection.
In small populations, genetic linkage between a polymorphic neutral locus and loci subject to selection, either against partially recessive mutations or in favor of heterozygotes, may result in an apparent selective advantage to heterozygotes at the neutral locus (associative overdominance) and a retardation of the rate of loss of variability by genetic drift at this locus. In large populations...
متن کاملAn inbreeding model of associative overdominance during a population bottleneck.
Associative overdominance, the fitness difference between heterozygotes and homozygotes at a neutral locus, is classically described using two categories of models: linkage disequilibrium in small populations or identity disequilibrium in infinite, partially selfing populations. In both cases, only equilibrium situations have been considered. In the present study, associative overdominance is r...
متن کاملHeterozygosity-fitness correlations: a time for reappraisal.
Owing to the remarkable progress of molecular techniques, heterozygosity-fitness correlations (HFCs) have become a popular tool to study the impact of inbreeding in natural populations. However, their underlying mechanisms are often hotly debated. Here we argue that these "debates" rely on verbal arguments with no basis in existing theory and inappropriate statistical testing, and that it is ti...
متن کاملShould individual fitness increase with heterozygosity?
Natural selection influences not only gamete frequencies in populations but also the multilocus fitness structures associated with segregating gametes. In particular, only certain patterns of multilocus fitnesses are consistent with the maintenance of stable multilocus polymorphisms. This paper offers support for the proposition that, at stable, viability-maintained, multilocus polymorphisms, t...
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ژورنال
عنوان ژورنال: Heredity
سال: 1998
ISSN: 0018-067X
DOI: 10.1038/sj.hdy.6883950